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Virux5% w/w
Square Pharmaceuticals PLC.
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Medicine overview
Indications of Acerux 5% w/w
Acerux 5% w/w cream is a herpes simplex virus (HSV) nucleoside analogue DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older.
Theropeutic Class
Topical Antiviral preparations
Pharmacology
Acerux 5% w/w is an antiviral drug active against herpes simplex virus. Acerux 5% w/w is a synthetic purine nucleoside analogue with cell culture and in vivo inhibitory activity against HSV types 1 (HSV-1) and 2 (HSV-2). The inhibitory activity of Acerux 5% w/w is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV. This viral enzyme converts Acerux 5% w/w into Acerux 5% w/w monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In cell culture, Acerux 5% w/w triphosphate stops replication of herpes viral DNA. This inhibition is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase.
Dosage & Administration of Acerux 5% w/w
Acerux 5% w/w cream should be applied five times per day for four days. Therapy should be initiated as early as possible following the onset of signs or symptoms of herpes labialis i.e., during the prodrome or when lesions appear. For adolescents 12 years of age and older, the dosage is the same as in adults.
Interaction of Acerux 5% w/w
Clinical experience has identified no interactions resulting from topical or systemic administration of other drugs concomitantly with Acerux 5% w/w cream. Due to minimal systemic absorption of Acerux 5% w/w cream, systemic drug interactions are unlikely.
Contraindications
Acerux 5% w/w cream is contraindicated in patients with known hypersensitivity to Acerux 5% w/w, valAcerux 5% w/w, or any component of the formulation.
Side Effects of Acerux 5% w/w
The most common adverse reactions at the site of topical application were dry lips, desquamation, dryness of skin, cracked lips, burning skin, pruritus, flakiness of skin, and stinging on skin; each adverse reaction occurred in less than 1% of patients receiving Acerux 5% w/w cream and placebo. Three patients on Acerux 5% w/w cream and one patient on placebo discontinued treatment due to an adverse event.
Pregnancy & Lactation
Pregnancy Category B. There are no adequate and well-controlled studies of Acerux 5% w/w cream in pregnant women. Acerux 5% w/w cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topically applied Acerux 5% w/w is excreted in breast milk. Systemic exposure following topical administration is minimal.
Precautions & Warnings
Acerux 5% w/w cream should only be applied on the affected external aspects of the lips and face in patients with herpes labialis. Because no data are available, application to human mucous membranes is not recommended. Acerux 5% w/w cream is intended for cutaneous use only and should not be used in the eye or inside the mouth or nose. Cream has a potential for irritation and contact. The effect of Acerux 5% w/w cream has not been established in immunocompromised patients.
Storage Conditions
Store Acerux 5% w/w cream at room temperature between 20°C to 25°C
Use In Special Populations
Pediatric Use: An open-label, uncontrolled trial with Acerux 5% w/w cream 5% was conducted in 113 patients aged 12 to 17 years with recurrent herpes labialis. In this trial, therapy was applied using the same dosing regimen as in adults and subjects were followed for adverse events. The safety profile was similar to that observed in adults. Safety and effectiveness in pediatric patients less than 12 years of age have not been established.Geriatric Use: Clinical studies of Acerux 5% w/w cream did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. Systemic absorption of Acerux 5% w/w after topical administration is minimal.
Frequently Asked Questions
What is Acerux 5% w/w used for?
Acerux 5% w/w cream is a herpes simplex virus (HSV) nucleoside analogue DNA polymerase inhibitor indicated for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older.
What is the dosage of Acerux 5% w/w?
Acerux 5% w/w cream should be applied five times per day for four days. Therapy should be initiated as early as possible following the onset of signs or symptoms of herpes labialis i.e., during the prodrome or when lesions appear. For adolescents 12 years of age and older, the dosage is the same as in adults.
What are the side effects of Acerux 5% w/w?
The most common adverse reactions at the site of topical application were dry lips, desquamation, dryness of skin, cracked lips, burning skin, pruritus, flakiness of skin, and stinging on skin; each adverse reaction occurred in less than 1% of patients receiving Acerux 5% w/w cream and placebo. Three patients on Acerux 5% w/w cream and one patient on placebo discontinued treatment due to an advers…
Who should not take Acerux 5% w/w?
Acerux 5% w/w cream is contraindicated in patients with known hypersensitivity to Acerux 5% w/w, valAcerux 5% w/w, or any component of the formulation.
What precautions should be taken with Acerux 5% w/w?
Acerux 5% w/w cream should only be applied on the affected external aspects of the lips and face in patients with herpes labialis. Because no data are available, application to human mucous membranes is not recommended. Acerux 5% w/w cream is intended for cutaneous use only and should not be used in the eye or inside the mouth or nose. Cream has a potential for irritation and contact. The effect o…
Is Acerux 5% w/w safe during pregnancy and breastfeeding?
Pregnancy Category B. There are no adequate and well-controlled studies of Acerux 5% w/w cream in pregnant women. Acerux 5% w/w cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topically applied Acerux 5% w/w is excreted in breast milk. Systemic exposure following topical administration is minimal.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.