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Inclaud100 mg
ACI Limited
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Medicine overview
Indications of Cilosta 100 mg
Cilosta 100 mg is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance.
Theropeutic Class
Peripheral Vasodilator drugs: Intermittent Claudication
Pharmacology
Cilosta 100 mg is a preparation of Cilosta 100 mg which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Dosage & Administration of Cilosta 100 mg
The recommended dosage of Cilosta 100 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.
Dosage of Cilosta 100 mg
The recommended dosage of Cilosta 100 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.Pediatric use: The safety and effectiveness of Cilosta 100 mg in pediatric patients have not been established.
Interaction of Cilosta 100 mg
Pharmacokinetic studies have demonstrated that Omeprazole and Erythromycin significantly increased the systemic exposure of Cilosta 100 mg and/or its major metabolites. Population pharmacokinetic studies showed higher concentrations of Cilosta 100 mg among patients concurrently treated with Diltiazem.
Contraindications
Cilosta 100 mg is contraindicated in patients with congestive heart failure of any severity. Cilosta 100 mg is also contraindicated in patients with known or suspected hypersensitivity to any of its components.
Side Effects of Cilosta 100 mg
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
Pregnancy & Lactation
There are no adequate and well controlled studies in pregnant women. Transfer of Cilosta 100 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Cilosta 100 mg.
Precautions & Warnings
Cilosta 100 mg should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Cilosta 100 mg and Clopidogrel.
Overdose Effects of Cilosta 100 mg
Severe headache, diarrhoea, hypotension, tachycardia, and possibly cardiac arrhythmias. Careful observation and supportive treatment are recommended.
Storage Conditions
Store in a cool & dry place, protected from light and moisture.
Use In Special Populations
Paediatric use: The safety and effectiveness of Cilosta 100 mg in paediatric patients have not been established.
Drug Classes
Peripheral Vasodilator drugs: Intermittent Claudication
Mode Of Action
Cilosta 100 mg is a preparation of Cilosta 100 mg which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Pregnancy
There are no adequate and well controlled studies in pregnant women. Transfer of Cilosta 100 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Cilosta 100 mg.
Frequently Asked Questions
What is Cilosta 100 mg used for?
Cilosta 100 mg is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance.
What is the dosage of Cilosta 100 mg?
The recommended dosage of Cilosta 100 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.Pediatric use: The safety and effectiveness of Cilosta 100 mg in pe…
What are the side effects of Cilosta 100 mg?
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
Who should not take Cilosta 100 mg?
Cilosta 100 mg is contraindicated in patients with congestive heart failure of any severity. Cilosta 100 mg is also contraindicated in patients with known or suspected hypersensitivity to any of its components.
What precautions should be taken with Cilosta 100 mg?
Cilosta 100 mg should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Cilosta 100 mg and Clopidogrel.
Is Cilosta 100 mg safe during pregnancy and breastfeeding?
There are no adequate and well controlled studies in pregnant women. Transfer of Cilosta 100 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Cilosta 100 mg.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.