DK400 IU+60 mcg+30 mcg

DK 400 IU+60 mcg+30 mcg is formulated to support bone metabolism, cardiovascular function, and normal physiological processes related to calcium balance and blood clotting.

Primary Indications

• Cardiovascular Health Support:
  Helps maintain healthy blood vessels and supports overall heart and circulatory system function.
• Calcium & Phosphorus Utilization:
  Contributes to the normal absorption and proper utilization of calcium and phosphorus in the body, essential for metabolic balance.
• Normal Blood Clotting:
  Supports the physiological process of blood coagulation through vitamin K–dependent mechanisms.
• Bone Health Maintenance:
  Helps maintain strong, healthy bones by supporting calcium deposition and bone mineralization.

Additional Supportive Role

• May help promote optimal bone density when combined with adequate nutrition and lifestyle.
• Supports proper calcium distribution, ensuring calcium is directed toward bones rather than soft tissues.

DK 400 IU+60 mcg+30 mcg is formulated with a balanced combination of fat-soluble vitamins that work synergistically to support bone health, calcium metabolism, and cardiovascular function.

Active Ingredients

• Vitamin D3 (400 IU)
  Supports calcium and phosphorus absorption from the intestine and plays a key role in maintaining bone strength and immune function.
• Vitamin K1 (60 mcg)
  Essential for normal blood clotting and contributes to the activation of proteins involved in coagulation pathways.
• Vitamin K2 (30 mcg)
  Helps regulate calcium distribution in the body by supporting its deposition in bones and preventing unwanted accumulation in soft tissues and arteries.

DK 400 IU+60 mcg+30 mcg works synergistically to regulate calcium metabolism, support bone mineralization, and maintain normal cardiovascular and coagulation functions through distinct but complementary physiological mechanisms.

Vitamin K1 (Phylloquinone)

Phylloquinone, commonly known as Vitamin K1, is a fat-soluble vitamin that is stable in air and moisture but sensitive to sunlight degradation. It is naturally present in green leafy vegetables. Vitamin K1 plays a vital role in the post-translational modification of specific proteins, particularly those involved in the blood coagulation cascade, thereby supporting normal blood clotting function.

Vitamin K2 (Menaquinone)

Vitamin K2 is essential for activating osteocalcin, a protein responsible for binding calcium and incorporating it into the bone matrix. This process promotes proper bone mineralization and skeletal strength. By directing calcium into bones, Vitamin K2 also helps reduce calcium deposition in soft tissues, supporting overall cardiovascular health.

Vitamin D3 (Cholecalciferol)

Vitamin D3 is crucial for normal bone growth, development, and maintenance of bone density. It enhances the body’s ability to absorb and utilize calcium and phosphorus effectively.

After oral absorption in the small intestine, Vitamin D3 binds to specific α-globulins and is transported to the liver, where it is converted to 25-hydroxyvitamin D3 (Calcidiol). It is then further hydroxylated in the kidneys to form the active metabolite 1,25-dihydroxyvitamin D3 (Calcitriol).

Calcitriol exerts its biological effects by binding to Vitamin D receptors (VDRs), which are widely distributed across various body tissues. This activation enhances intestinal calcium absorption and contributes to overall calcium homeostasis. Being fat-soluble, Vitamin D3 has a long half-life of approximately 50 days and is stored in tissues such as fat and muscle. Excess amounts are eliminated through feces and urine.

DK 400 IU+60 mcg+30 mcg may interact with certain medications that affect blood clotting or vitamin metabolism.

Key Interactions

• Coumarin-type anticoagulants (e.g., warfarin):
  Vitamin K may reduce the anticoagulant effect and antagonize their action.
• Anticonvulsants:
  Drugs such as carbamazepine, phenytoin, phenobarbital, and primidone may reduce the effectiveness of vitamin K and vitamin D3 by altering their metabolism.

Other Drug Interactions with Vitamin D3

• Carbamazepine
• Dactinomycin
• Diuretics
• Fosphenytoin
• Miconazole
• Phenobarbital
• Phenytoin
• Primidone

Summary

Vitamin K can interfere with anticoagulant therapy, while several anticonvulsants and other drugs may reduce the effectiveness of Vitamin D3. Careful monitoring or dose adjustment may be required when used concurrently with these medications.

DK 400 IU+60 mcg+30 mcg is generally well tolerated when used in the recommended dose, and most individuals do not experience significant adverse effects.

Tolerability Profile

• No common or clinically significant side effects are typically reported at standard therapeutic doses.

Rare Possibilities (Uncommon)

• Mild gastrointestinal discomfort in sensitive individuals (rare and usually transient)

DK 400 IU+60 mcg+30 mcg IS generally considered safe during pregnancy and lactation when used in recommended doses.

Clinical Considerations

• Supports maternal bone health and normal calcium metabolism during pregnancy.
• Contributes to healthy fetal skeletal development.
• During breastfeeding, helps maintain adequate maternal vitamin status for optimal nutritional support.

Store at a cool & dry place below 30°C temperature, Protect from direct sunlight & moisture. Do not freeze.