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Lacomax50 mg

Tablet

Lacosamide
ByIncepta Pharmaceuticals Ltd.
MRP ৳ 120.008% Off
Best PriceTk 110.40/10's Strip
1
Section

Medicine overview

Indications of Lacomax 50 mg

Lacomax 50 mg is indicated for the treatment of partial-onset seizures in patients 4 years of age and older. As the safety of Lacomax 50 mg injection has not been established in pediatric patients, Lacomax 50 mg injection is indicated for the treatment of partial-onset seizures only in adult patients (17 years of age and older)

Dosage of Lacomax 50 mg

Adults (17 years and older): Initial dosage for monotherapy is 100 mg twice daily; initial dosage for adjunctive therapy is 50 mg twice daily; maximum recommended dosage for monotherapy and adjunctive therapy is 200 mg twice daily Pediatric Patients 4 Years to less than 17 years: The recommended dosage is based on body weight and is administered orally twice daily. Increase dosage based on clinical response and tolerability, no more frequently than once per weekInjection: for intravenous and adult use only when oral administration is temporarily not feasible; dosing regimen is the same as oral regimen; administer over 15 to 60 minutes; obtaining ECG before initiation is recommended in certain patients

Interaction of Lacomax 50 mg

Strong CYP3A4 or CYP2C9 Inhibitors: Patients with renal or hepatic impairment who are taking strong inhibitors of CYP3A4 and CYP2C9 may have a significant increase in exposure to Lacomax 50 mg. Dose reduction may be necessary in these patients.Concomitant Medications that Prolong PR Interval: Lacomax 50 mg should be used with caution in patients on concomitant medications that prolong PR interval, because of a risk of AV block or bradycardia, e.g., beta-blockers and calcium channel blockers. In such patients, obtaining an ECG before beginning Lacomax 50 mg, and after Lacomax 50 mg is titrated to steady-state, is recommended. In addition, these patients should be closely monitored if they are administered Lacomax 50 mg through the intravenous route

Contraindications

None

Side Effects of Lacomax 50 mg

Adjunctive therapy: Most common adverse reactions in adults (≥10% and greater than placebo) are diplopia, headache, dizziness, nauseaMonotherapy: Most common adverse reactions are similar to those seen in adjunctive therapy studiesPediatric patients: Adverse reactions are similar to those seen in adult patients

Precautions & Warnings

Monitor patients for suicidal behavior and ideationLacomax 50 mg may cause dizziness and ataxiaCardiac Rhythm and Conduction Abnormalities: Obtaining ECG before beginning and after titration to steady-state maintenance is recommended in patients with known cardiac conduction problems, taking drugs known to induce PR interval prolongation, or with severe cardiac disease; closely monitor these patientsLacomax 50 mg may cause syncopeLacomax 50 mg should be gradually withdrawn to minimize the potential of increased seizure frequencyDrug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multi-Organ Hypersensitivity: Discontinue if no alternate etiology

Storage Conditions

Store at 20°C to 25°C

Drug Classes

Atypical anti-depressant drugs

Mode Of Action

It is proposed that Lacomax 50 mg's inhibition of sodium channels is responsible for analgesia. Lacomax 50 mg may be selective for inhibiting depolarized neurons rather than neurons with normal resting potentials. Pain and nociceptor hyperexcitability are associated with neural membrane depolarization. Lacomax 50 mg binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein which is expressed primarily in the nervous system and is involved in neuronal differentiation and control of axonal outgrowth. The role CRMP-2 of binding in seizure control is hasn't been elucidated.

Pregnancy

Pregnancy: Based on animal data, may cause fetal harm

Pediatric Uses

Dose adjustment is recommended for severe renal impairment. Dose adjustment is recommended for mild or moderate hepatic impairment; use in patients with severe hepatic impairment is not recommended

Frequently Asked Questions

What is Lacomax 50 mg used for?

Lacomax 50 mg is indicated for the treatment of partial-onset seizures in patients 4 years of age and older. As the safety of Lacomax 50 mg injection has not been established in pediatric patients, Lacomax 50 mg injection is indicated for the treatment of partial-onset seizures only in adult patients (17 years of age and older)

What is the dosage of Lacomax 50 mg?

Adults (17 years and older): Initial dosage for monotherapy is 100 mg twice daily; initial dosage for adjunctive therapy is 50 mg twice daily; maximum recommended dosage for monotherapy and adjunctive therapy is 200 mg twice daily Pediatric Patients 4 Years to less than 17 years: The recommended dosage is based on body weight and is administered orally twice daily. Increase dosage based on clinica…

What are the side effects of Lacomax 50 mg?

Adjunctive therapy: Most common adverse reactions in adults (≥10% and greater than placebo) are diplopia, headache, dizziness, nauseaMonotherapy: Most common adverse reactions are similar to those seen in adjunctive therapy studiesPediatric patients: Adverse reactions are similar to those seen in adult patients

Who should not take Lacomax 50 mg?

None

What precautions should be taken with Lacomax 50 mg?

Monitor patients for suicidal behavior and ideationLacomax 50 mg may cause dizziness and ataxiaCardiac Rhythm and Conduction Abnormalities: Obtaining ECG before beginning and after titration to steady-state maintenance is recommended in patients with known cardiac conduction problems, taking drugs known to induce PR interval prolongation, or with severe cardiac disease; closely monitor these patie…

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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