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Santinal MR200 mg

Capsule

Dipyridamole
ByUnimed Unihealth MFG. Ltd.
MRP ৳ 10.0010 % Off
Best PriceTk 9.00/piece
1
Section

Medicine overview

Indications of Santinal MR 200 mg

Santinal MR 200 mg is indicated in Prophylaxis of thromboembolism following cardiac valve replacement, Secondary prophylaxis of stroke or transient ischaemic attack

Theropeutic Class

Anti-platelet drugs

Pharmacology

Santinal MR 200 mg causes an accumulation of adenosine, adenine nucleotides and cAMP by inhibiting the activity of adenosine deaminase and phosphodiesterase thus inhibiting platelet aggregation and may cause vasodilation.

Dosage of Santinal MR 200 mg

Prophylaxis of thromboembolism following cardiac valve replacement: Adult: 300-600 mg/day in divided doses with an oral anticoagulant. Child: 5 mg/kg/day in divided doses. Secondary prophylaxis of stroke or transient ischaemic attack: Adult: As modified-release preparation: 200 mg bid, with or without aspirin.

Administration of Santinal MR 200 mg

Should be taken on an empty stomach. Take 1 hr before meals. May be taken with meals to reduce GI discomfort.

Interaction of Santinal MR 200 mg

Aminophylline may reverse vasodilatation effect. Useful combination with aspirin in prevention of thromboembolism. Efficacy reduced by concurrent admin of antacids. Concurrent use may increase the cardiotoxic effects of adenosine.

Contraindications

Hypersensitivity. Peptic ulcer.

Side Effects of Santinal MR 200 mg

GI disturbances, headache, dizziness, faintness, facial flushing, skin rash, liver dysfunction, angina. Large doses may lower BP.

Pregnancy & Lactation

Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Precautions & Warnings

In patients with rapidly worsening angina, subvalvular aortic stenosis, haemodynamic instability associated with recent MI or coagulation disorders esp when given IV during myocardial imaging. Hypotension, unstable angina, aortic stenosis. Pregnancy and lactation. Safety and efficacy are not established in childn < 12 yrs.

Overdose Effects of Santinal MR 200 mg

Symptoms: warm feeling, flushes, sweating, restlessness, weakness, dizziness, hypotension and tachycardia. Management: treatment is symptomatic. Empty stomach by gastric lavage. Haemodialysis unlikely to be useful.

Storage Conditions

Store below 25° C.

Drug Classes

Anti-platelet drugs

Mode Of Action

Santinal MR 200 mg causes an accumulation of adenosine, adenine nucleotides and cAMP by inhibiting the activity of adenosine deaminase and phosphodiesterase thus inhibiting platelet aggregation and may cause vasodilation.

Pregnancy

Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Frequently Asked Questions

What is Santinal MR 200 mg used for?

Santinal MR 200 mg is indicated in Prophylaxis of thromboembolism following cardiac valve replacement, Secondary prophylaxis of stroke or transient ischaemic attack

What is the dosage of Santinal MR 200 mg?

Prophylaxis of thromboembolism following cardiac valve replacement: Adult: 300-600 mg/day in divided doses with an oral anticoagulant. Child: 5 mg/kg/day in divided doses. Secondary prophylaxis of stroke or transient ischaemic attack: Adult: As modified-release preparation: 200 mg bid, with or without aspirin.

What are the side effects of Santinal MR 200 mg?

GI disturbances, headache, dizziness, faintness, facial flushing, skin rash, liver dysfunction, angina. Large doses may lower BP.

Who should not take Santinal MR 200 mg?

Hypersensitivity. Peptic ulcer.

What precautions should be taken with Santinal MR 200 mg?

In patients with rapidly worsening angina, subvalvular aortic stenosis, haemodynamic instability associated with recent MI or coagulation disorders esp when given IV during myocardial imaging. Hypotension, unstable angina, aortic stenosis. Pregnancy and lactation. Safety and efficacy are not established in childn < 12 yrs.

Is Santinal MR 200 mg safe during pregnancy and breastfeeding?

Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.

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