Temixil10 mg

Name: Temixil 10 mg
Brand: Temixil
SKU: 19528
Price: 9.00 BDT
Availability: InStock

Tablet

Temazepam

ByRenata Limited

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Best PriceTk 9.00/piece

Medicine overview

Indications of Temixil 10 mg

Temixil 10 mg is indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temixil 10 mg should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy ... Read moreTemixil 10 mg is indicated for the short-term treatment of insomnia (generally 7 to 10 days). For patients with short-term insomnia, instructions in the prescription should indicate that Temixil 10 mg should be used for short periods of time (7 to 10 days). The clinical trials performed in support of efficacy were 2 weeks in duration with the final formal assessment of sleep latency performed at the end of treatment.

Dosage of Temixil 10 mg

While the recommended usual adult dose is 15 mg before retiring, 7.5 mg may be sufficient for some patients, and others may need 30 mg. In transient insomnia, a 7.5 mg dose may be sufficient to improve sleep latency. In elderly or debilitated patients, it is recommended that therapy be initiated with 7.5 mg until individual responses are determined.Pediatric Use: Safety and effectiveness in pediatric patients have not been established.

Contraindications

Benzodiazepines may cause fetal harm when administered to a pregnant woman. An increased risk of congenital malformations associated with the use of diazepam and chlordiazepoxide during the first trimester of pregnancy has been suggested in several studies. Transplacental distribution has resulted in neonatal CNS depression following the ingestion of therapeutic doses of a benzodiazepine hypnotic during the last weeks of pregnancy.Reproduction studies in animals with Temixil 10 mg were performed in rats and rabbits. In a perinatal-postnatal study in rats, oral doses of 60 mg/kg/day resulted in increasing nursling mortality. Teratology studies in rats demonstrated increased fetal resorptions at doses of 30 and 120 mg/kg in one study and increased occurrence of rudimentary ribs, which are considered skeletal variants, in a second study at doses of 240 mg/kg or higher. In rabbits, occasional abnormalities such as exencephaly and fusion or asymmetry of ribs were reported without dose relationship. Although these abnormalities were not found in the concurrent control group, they have been reported to occur randomly in historical controls. At doses of 40 mg/kg or higher, there was an increased incidence of the 13th rib variant when compared to the incidence in concurrent and historical controls.Temixil 10 mg is contraindicated in women who are or may become pregnant. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Patients should be instructed to discontinue the drug prior to becoming pregnant. The possibility that a woman of childbearing potential may be pregnant at the time of institution of therapy should be considered.

Side Effects of Temixil 10 mg

The most common side effects of Temixil 10 mg are: drowsiness headache tiredness nervousness dizziness nausea

Precautions & Warnings

Since the risk of the development of oversedation, dizziness, confusion, and/or ataxia increases substantially with larger doses of benzodiazepines in elderly and debilitated patients, 7.5 mg of Temixil 10 mg is recommended as the initial dosage for such patients. Temixil 10 mg should be administered with caution in severely depressed patients or those in whom there is any evidence of latent depression; it should be recognized that suicidal tendencies may be present and protective measures may be necessary. The usual precautions should be observed in patients with impaired renal or hepatic function and in patients with chronic pulmonary insufficiency. If Temixil 10 mg is to be combined with other drugs having known hypnotic properties or CNS-depressant effects, consideration should be given to potential additive effects. The possibility of a synergistic effect exists with the co-administration of Temixil 10 mg and diphenhydramine. One case of stillbirth at term has been reported 8 hours after a pregnant patient received Temixil 10 mg and diphenhydramine. A cause and effect relationship has not yet been determined.

Storage Conditions

Store Temixil 10 mg at room temperature, 20° to 25°C. Keep Temixil 10 mg and all medicines out of reach of children.

Drug Classes

Benzodiazepine antagonist, Benzodiazepine hypnotics, Benzodiazepine sedatives

Mode Of Action

Gamma-Aminobutyric acid (GABA) is considered the principal inhibitory neurotransmitter in the human body. When GABA binds to GABA(a) receptors found in neuron synapses, chloride ions are conducted across neuron cell membranes via an ion channel in the receptors. With enough chloride ions conducted, the local, associated neuron membrane potentials are hyperpolarized - making it more difficult or less likely for action potentials to fire, ultimately resulting in less excitation of the neurons.Subsequently, benzodiazepines like Temixil 10 mg can bind to benzodiazepine receptors that are components of various varieties of GABA(a) receptors. This binding acts to enhance the effects of GABA by increasing GABA affinity for the GABA(a) receptor, which ultimately enhances GABA ligand binding at the receptors. This enhanced ligand binding of the inhibitory neurotransmitter GABA to the receptors increases the aforementioned chloride ion conduction (perhaps reportedly via an increase in the frequency of the chloride channel opening), resulting in a hyperpolarized cell membrane that prevents further excitation of the associated neuron cells. Combined with the notion that such benzodiazepine receptor associated GABA(a) receptors exist both peripherally and in the CNS, this activity consequently facilitates various effects like sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action

Pregnancy

Pregnancy Category X. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Temixil 10 mg is administered to a nursing woman.

Frequently Asked Questions

What is Temixil 10 mg used for?

What is the dosage of Temixil 10 mg?

What are the side effects of Temixil 10 mg?

The most common side effects of Temixil 10 mg are: drowsiness headache tiredness nervousness dizziness nausea

Who should not take Temixil 10 mg?

What precautions should be taken with Temixil 10 mg?

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.