Torel(25.40 mg+14.30 mg+4.20 mg+0.05 mg)/gm

Muscle pain Sprains, strains and sports injuries, headache bruising, fibrositis, neuralgia, pain due to herpes zoster, osteoarthritis

Each gm muscle rub contains- L-Menthol 25.40 mg D-camphor 14.30 mg  Methyl Salicylate 4.20 mg Oleoresin Capsicum 0.05 mg

Herbal and Nutraceuticals, Topical Analgesics, Topical anti-inflammatory preparations

Capsicum species are known to be very strong local stimulants in the circulatory system. Its reduction of thromboxane B2 formation and erythrocyte hemolysis suggests a membrane stabilizing property that interferes with the activation of phospholipase A2. Capsicum activates nociceptive fbres, which induces the release of excitatory neurotransmitters, bind to specific vanilloid (capsaicin) receptors and its effects are reversible. Capsicum induces selective analgesic effect by depleting substance P, a neuropeptide of 11 amino acids that mediates the transmission and modulation of pain impulses from the peripheral nerves to the spinal column. Capsicum initially stimulates substance P release from peripheral sensory C type nerve fibers, then prevents its re-uptake and also blocks its transport within the neuron, which causes its eventual depletion resulting in analgesia. Methyl salicylic acid is similar to that of Aspirin that shows anesthetic properties by blocking the voltage-operated sodium channels in pain-receptor neurons.Menthol molecule binds and stimulates the TRPM-8 receptor protein that produces a sensation of cold (pain in extreme cases) when stimulated.Camphor has been approved by FDA for topical use as a pain reliever and anesthetic. It acts as counter irritant and numbs the nerve endings that inhibit the transmission of pain sensation.

In rare cases hypersensitivity reaction may occur. Inhalation of medicine may cause bronchoconstriction.

There is no information available about restriction of this medicine during pregnancy and lactation. May be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks of fetus.

Avoid use on broken or inflamed skin, eyes and the mucous membranes. Rinse with cold water if accidental contact occurs. Do not cover immediately after application. Wash your hands thoroughly after application. If itching or irritation occurs discontinue it.

Store at a cool, dry place and away from direct sunlight. Keep the medicine out of the reach of children.