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Vasocil50 mg
Ibn-Sina Pharmaceuticals Ltd.
৳6.32
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Medicine overview
Indications of Zocil 50 mg
Zocil 50 mg is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance.
Theropeutic Class
Peripheral Vasodilator drugs: Intermittent Claudication
Pharmacology
Zocil 50 mg is a preparation of Zocil 50 mg which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Dosage & Administration of Zocil 50 mg
The recommended dosage of Zocil 50 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.
Dosage of Zocil 50 mg
The recommended dosage of Zocil 50 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.Pediatric use: The safety and effectiveness of Zocil 50 mg in pediatric patients have not been established.
Interaction of Zocil 50 mg
Pharmacokinetic studies have demonstrated that Omeprazole and Erythromycin significantly increased the systemic exposure of Zocil 50 mg and/or its major metabolites. Population pharmacokinetic studies showed higher concentrations of Zocil 50 mg among patients concurrently treated with Diltiazem.
Contraindications
Zocil 50 mg is contraindicated in patients with congestive heart failure of any severity. Zocil 50 mg is also contraindicated in patients with known or suspected hypersensitivity to any of its components.
Side Effects of Zocil 50 mg
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
Pregnancy & Lactation
There are no adequate and well controlled studies in pregnant women. Transfer of Zocil 50 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Zocil 50 mg.
Precautions & Warnings
Zocil 50 mg should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Zocil 50 mg and Clopidogrel.
Overdose Effects of Zocil 50 mg
Severe headache, diarrhoea, hypotension, tachycardia, and possibly cardiac arrhythmias. Careful observation and supportive treatment are recommended.
Storage Conditions
Store in a cool & dry place, protected from light and moisture.
Use In Special Populations
Paediatric use: The safety and effectiveness of Zocil 50 mg in paediatric patients have not been established.
Drug Classes
Peripheral Vasodilator drugs: Intermittent Claudication
Mode Of Action
Zocil 50 mg is a preparation of Zocil 50 mg which is a quinolinone derivative. The mechanism of action is to specifically inhibit cellular phosphodiesterase III (PDE III) and suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.
Pregnancy
There are no adequate and well controlled studies in pregnant women. Transfer of Zocil 50 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Zocil 50 mg.
Frequently Asked Questions
What is Zocil 50 mg used for?
Zocil 50 mg is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance.
What is the dosage of Zocil 50 mg?
The recommended dosage of Zocil 50 mg is 100 mg bid, taken at least half an hour before or two hours after breakfast and dinner. A dose of 50 mg bid should be considered during coadministration of Fluconazole, Ketoconazole, Itraconazole, Erythromycin, Clarithromycin, Fluvoxamine, Fluoxetine, Nefazodone, Sertraline and Diltiazem.Pediatric use: The safety and effectiveness of Zocil 50 mg in pediatri…
What are the side effects of Zocil 50 mg?
The most common side effects are headache, diarrhoea, vomiting, leg cramps, rash etc. The less frequent side effects are anorexia and edema.
Who should not take Zocil 50 mg?
Zocil 50 mg is contraindicated in patients with congestive heart failure of any severity. Zocil 50 mg is also contraindicated in patients with known or suspected hypersensitivity to any of its components.
What precautions should be taken with Zocil 50 mg?
Zocil 50 mg should be used with caution in patients with any degree of heart failure. There is no information with respect to the efficacy or safety of the concurrent use of Zocil 50 mg and Clopidogrel.
Is Zocil 50 mg safe during pregnancy and breastfeeding?
There are no adequate and well controlled studies in pregnant women. Transfer of Zocil 50 mg into milk has been reported in experimental animals. Because of the potential risk to nursing infants, a decision should be made to discontinue nursing or to discontinue Zocil 50 mg.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.