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Medicine overview
Indications of Zoton 15 mg
Zoton 15 mg is indicated for:
Short term treatment of active duodenal ulcer
Maintenance of healed duodenal ulcers
Short term treatment of active benign gastric ulcers
Short term treatment of active erosive esophagitis
Maintenance of healing of erosive esophagitis ... Read moreZoton 15 mg is indicated for:
Short term treatment of active duodenal ulcer
Maintenance of healed duodenal ulcers
Short term treatment of active benign gastric ulcers
Short term treatment of active erosive esophagitis
Maintenance of healing of erosive esophagitis
Pathological hypersecretory conditions including Zollinger- Ellison Syndrome
H. pylori eradication to reduce the risk of duodenal ulcer recurrence
Theropeutic Class
Proton Pump Inhibitor
Pharmacology
Zoton 15 mg is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.
Dosage & Administration of Zoton 15 mg
Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.
Dosage of Zoton 15 mg
Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses.Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily.Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks.
Interaction of Zoton 15 mg
Zoton 15 mg appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Zoton 15 mg on the oral combined contraceptive pill. Further assessment is currently underway. Physiological changes similar to those found with Omeprazole are likely to take place because of the reduction in gastric acid, which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.
Contraindications
Zoton 15 mg is contraindicated in patients with known hypersensitivity to any component of the formulation.
Side Effects of Zoton 15 mg
Severe or irreversible adverse effects: The possible induction of carcinoid tumors by profound acid suppression, and a rise in serum gastrin may occur. There is a rise in serum gastrin levels in the first 3 months of treatment, which are then maintained though at a lower level than those found in pernicious anaemia. Long term treatment with a proton pump inhibitor in patients with Helicobacter pylori infection may accelerate the development of atrophic gastritis.Symptomatic adverse effect: Dose dependent diarrhoea occurs with an incidence of about 4% at 30 mg per day, rising to 8% at 60 mg per day. Headache occurs in 2-3% of treated patients
Pregnancy & Lactation
Zoton 15 mg should be avoided in pregnancy unless there are compelling reasons.
Precautions & Warnings
Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.
Storage Conditions
Store at 25° C.
Use In Special Populations
Neonates:There is no relevant human data. The drug is not recommended for use with neonates.Children: The youngest person to have received Zoton 15 mg in clinical trials was 13 years old.The Elderly: No problems have been encoun- tered in clinical use and there has been no increase in adverse drug reaction in the elderly.
Drug Classes
Proton Pump Inhibitor
Mode Of Action
Zoton 15 mg is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.
Pregnancy
Zoton 15 mg should be avoided in pregnancy unless there are compelling reasons.
Pediatric Uses
Neonates:There is no relevant human data. The drug is not recommended for use with neonates.Children: The youngest person to have received Zoton 15 mg in clinical trials was 13 years old.The Elderly: No problems have been encoun- tered in clinical use and there has been no increase in adverse drug reaction in the elderly.
Frequently Asked Questions
What is Zoton 15 mg used for?
Zoton 15 mg is indicated for: Short term treatment of active duodenal ulcer Maintenance of healed duodenal ulcers Short term treatment of active benign gastric ulcers Short term treatment of active erosive esophagitis Maintenance of healing of erosive esophagitis ... Read moreZoton 15 mg is indicated for: Short term treatment of active duodenal ulcer Maintenance of healed duodenal ulcers Short ter…
What is the dosage of Zoton 15 mg?
Benign gastric ulcer: 30 mg daily in the morning for 8 weeks.Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg.NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed.Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120…
What are the side effects of Zoton 15 mg?
Severe or irreversible adverse effects: The possible induction of carcinoid tumors by profound acid suppression, and a rise in serum gastrin may occur. There is a rise in serum gastrin levels in the first 3 months of treatment, which are then maintained though at a lower level than those found in pernicious anaemia. Long term treatment with a proton pump inhibitor in patients with Helicobacter pyl…
Who should not take Zoton 15 mg?
Zoton 15 mg is contraindicated in patients with known hypersensitivity to any component of the formulation.
What precautions should be taken with Zoton 15 mg?
Gastric malignancy should be ruled out. Hepatic impairment. Pregnancy and lactation.
Is Zoton 15 mg safe during pregnancy and breastfeeding?
Zoton 15 mg should be avoided in pregnancy unless there are compelling reasons.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.